Protein Modification Reagents
![eMolecules Broadpharm / endo-BCN-PEG8-acid / 25mg / 354974895 / BP-23768 / 98.000 / 2126805-02-3 / [null] / 617.733 / C30H51NO12](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502477422.JPG-250.jpg)
eMolecules Broadpharm / endo-BCN-PEG8-acid / 25mg / 354974895 / BP-23768 / 98.000 / 2126805-02-3 / [null] / 617.733 / C30H51NO12
Broadpharm / endo-BCN-PEG8-acid / 25mg / 354974895 / BP-23768 / 98.000 / 2126805-02-3 / [null] / 617.733 / C30H51NO12
Medchemexpress LLC 2,5-dioxopyrrolidin-1-yl m-PEG24 carboxylate | 2395839-96-8 | MFCD11041155 | 99.7% | 1214.39 g·mol⁻¹ | C54H103NO28 | 5 MG
m-PEG24-NHS ester is a methoxy-terminated polyethylene glycol (PEG) linker functionalized with an N-hydroxysuccinimide (NHS) ester. The NHS group reacts with primary amines to form stable amide bonds, enabling bioconjugation and linker installation in medicinal chemistry workflows such as PROTAC assembly. The reagent is provided with high purity for research applications.
- Methoxy-terminated PEG24 linker with NHS ester reactivity.
- Reacts with primary amines to form stable amide bonds.
- Compatible with PROTAC synthesis and general bioconjugation.
- High purity suitable for research use.
- Molecular weight approximately 1214.39 g·mol⁻¹.
Medchemexpress LLC Protac MDM2 degrader-2 | 2249944-99-6 | MFCD32197289 | 96.0% | 1391.22 g/mol | C70H76Cl4N10O12 | 5 MG
PROTAC MDM2 Degrader-2 is a bifunctional small molecule degrader designed to recruit an E3 ligase to MDM2, promoting ubiquitination and proteasomal degradation of MDM2. The compound leads to p53 stabilization and shows antiproliferative effects in cellular assays. It is supplied for research use with characterized purity, formula, and storage recommendations.
eMolecules Broadpharm / m-PEG36-Mal / 100mg / 279709052 / BP-22751 / 98.000 / 88504-24-9 / MFCD21363231 / 1768.087 / C80H154N2O39
Broadpharm / m-PEG36-Mal / 100mg / 279709052 / BP-22751 / 98.000 / 88504-24-9 / MFCD21363231 / 1768.087 / C80H154N2O39
Medchemexpress LLC Mal-PEG2-oxyamine | 1146245-73-9 | MFCD00209801 | 95.0% | 244.24 g·mol⁻¹ | C10H16N2O5 | 5 MG
Mal-PEG2-oxyamine is a PEG-based bifunctional linker used in the synthesis of proteolysis-targeting chimeras (PROTACs). It contains a maleimide group and an oxyamine moiety separated by a PEG2 spacer, enabling thiol-maleimide coupling and oxime ligation for efficient bioconjugation. The free base can be prone to instability; a TFA salt is available to improve stability.
- Bifunctional maleimide and oxyamine reactive groups.
- PEG2 spacer provides flexibility and improved solubility.
- Compatible with thiol conjugation and oxime ligation chemistries.
- Offered as a small-scale reagent (e.g., 5 mg) with reported purity around 95%.
Medchemexpress LLC Mal-PEG2-oxyamine | 1146245-73-9 | 95.0% | C10H16N2O5 | 10MG
Mal-PEG2-oxyamine is a bifunctional PEG-based linker for use in the synthesis of PROTACs. It features a maleimide group and an aminooxy (oxyamine) group connected by a short PEG2 spacer, permitting orthogonal conjugation to thiol and carbonyl functionalities for targeted protein degradation research. The product is supplied with a reported purity of 95% and includes storage and solubility guidance for research applications.
- Bifunctional maleimide and aminooxy reactive groups.
- PEG2 spacer provides a short, flexible linkage.
- Enables selective conjugation to thiol and carbonyl partners.
- Reported purity supports synthetic and analytical use.
- Includes storage and solubility recommendations for stability.
Bioworld PEG 20%, 600 mL Liquid, 3.5 M Ammonium Acetate, Non-hazardous
This product is a precisely formulated buffer solution designed for various life science applications, particularly protein crystallization. It contains 20% polyethylene glycol (PEG) 8000 and 3.5 M ammonium acetate, offering consistent performance and a stable environment for experimental procedures. This ready-to-use liquid reagent simplifies preparation steps for researchers.
- Contains 20% polyethylene glycol
- Uses 3.5 M ammonium acetate
- Engineered for protein crystallization
- Ready-to-use liquid form
- Stable composition ensures reproducibility
- Non-hazardous for safe handling
- Pack size of 600 mL (6 x 100 mL)
- Has a shelf life of 2 years
- Store at room temperature
Medchemexpress LLC Pomalidomide-PEG6-C2-COOH | 2225148-49-0 | MFCD32173791 | >98.0% | C28H39N3O12 | 10MG
Pomalidomide-PEG6-C2-COOH is a cereblon E3 ligase ligand-linker conjugate that combines a pomalidomide-derived cereblon binder with a six-unit polyethylene glycol spacer terminating in a carboxylic acid. Supplied as a high-purity building block, it is intended for use in the synthesis of PROTACs and other targeted protein degradation molecules, enabling modular attachment to warheads or additional linker chemistry.
- Cereblon-binding pomalidomide core for E3 ligase recruitment.
- PEG6 spacer provides a flexible, water-compatible linker.
- Terminal carboxylic acid enables amide coupling and conjugation.
- High chemical purity suitable for medicinal chemistry research.
- Available in multiple small-scale package sizes for screening and optimisation.
- Stable under recommended storage conditions for reliable handling.
Medchemexpress LLC Biotin-PEG4-alcohol | 1217609-84-1 | 98.0% | C18H33N3O6S | 10MG
Biotin-PEG4-OH is a biotinylated polyethylene glycol linker with a terminal hydroxyl group, designed for use as a flexible spacer and affinity tag in chemical biology and PROTAC synthesis. The PEG4 spacer increases solubility and reduces steric hindrance while enabling conjugation to biomolecules and small-molecule ligands.
Medchemexpress LLC Dspe-peg4-dbco | 2112738-14-2 | MFCD30828684 | 95.0% | C71H116N3O15P | 10MG
DSPE-PEG4-DBCO is a lipid-polyethylene glycol conjugate bearing a dibenzocyclooctyne (DBCO) reactive group used for copper-free click chemistry and bioconjugation. It enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-functionalized partners, facilitating liposome functionalization, surface modification, and linker assembly in aqueous and physiological conditions.
- Provides a DBCO reactive handle for copper-free SPAAC.
- Contains a PEG4 spacer for improved solubility and reduced steric hindrance.
- Includes a lipid anchor for incorporation into lipid bilayers and liposomes.
- Suitable for bioconjugation under physiological conditions.
- High purity for consistent reaction performance.